Scientists at Massachusetts General Hospital are hoping to prove that type 1 diabetes can be reversed with the help of a generic drug.
The five-year long, phase II clinical trial, which received approval from the U.S. Food and Drug Administration, was announced Sunday during the 75th Scientific Sessions of the American Diabetes Association, one of the largest diabetes gathering in the country.
Scientists have already tested the bacillus Calmette-Guerin vaccine in mice, showing the drug’s ability to eliminate abnormal white blood cells responsible for the autoimmune disease.
Phase 1 trials in humans, results of which were published in August 2012 in the journal PLOS Medicine, showed that two injections spaced four weeks apart led to temporarily elimination of the T cells and a moderate return of insulin secretion.
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